Ecologic® RELIEF formulation inside

Figure 1: Ecologic® RELIEF is a multispecies probiotic specifically developed to enhance bowel movement (level 1)and hereby reduce constipation.
Figure 1: Ecologic® RELIEF is a multispecies probiotic specifically developed to enhance bowel movement (level 1)and hereby reduce constipation.

Ecologic® RELIEF is a multispecies probiotic product, specifically developed to ease away constipation. Ecologic® RELIEF has been developed in close cooperation with the Children’s Hospital of the Academic Medical Centre (AMC) of the University of Amsterdam. The bacterial strains of Ecologic® RELIEF have been specifically selected for their capacity to (figure 2):

  • inhibit Clostridium difficile and Staphylococcus aureus (level 1)
  • produce lactic acid to improve the motility and peristalsis of the intestine1 (level 1).

The selected strain combination from the Ecologic® Relief formulation:

  • Bifidobacterium bifidum       W23
  • Bifidobacterium lactis            W52
  • Bifidobacterium longum        W108
  • Lactobacillus casei                 W79
  • Lactobacillus plantarum         W62
  • Lactobacillus rhamnous         W71

Probiotic formulation for reduction of constipation

Constipation is one of the most common gastrointestinal conditions affecting 12-27% of the general population.2 Constipation can be a temporary or chronic problem. Chronic constipation often starts already during childhood.

A widely used diagnostic tool to define chronic constipation are the Rome III criteria. According to these criteria for constipation, a patient must have experienced at least 2 of the following symptoms over the preceding 3 months:

  • Fewer than 3 bowel movements per week
  • Straining
  • Lumpy or hard stools
  • Sensation of anorectal obstruction
  • Sensation of incomplete defecation
  • Manual manoeuvring required to defecate

The cause of constipation is often unknown. Mechanisms thought to play a role are a reduced peristalsis and a shift in the intestinal microbiota.3 It is suggested that the intestinal microbiota of constipated persons is in dys­biosis. It for example contains higher concentrations of Clostridia and Staphylococci compared to the intestinal microbiota of non-constipated persons.4 Currently, (childhood) constipation is often treated with laxatives. Unfortunately, 40% of these children do not react well to this treatment.5 Research has shown that probiotics improve whole gut transit time, stool frequency and stool consistency and can soften stools by stimulating water- and electrolyte secretion, indicating a beneficial effect.3 6 Administration of probiotics are a promising and effective treatment for constipation.

Figure 2: Risk factors of constipation
Figure 2: Risk factors of constipation

Clinical support

Ecologic® RELIEF has been tested in a clinical study, organised in collaboration with the Children’s Hospital of the Academic Medical Centre of the University of Amsterdam. Twenty children suffering from constipation used the product for four weeks (once daily). Results showed that Ecologic® RELIEF was able to induce a significant increase in the amount of bowel movements per week, a significant decrease in the amount of abdominal pain and a significant decrease in the amount of faecal incontinence (dirty underwear). No side effects were reported6 (figure 3).

In addition, Ecologic® RELIEF has been tested in an open-label study carried out again in collaboration with the AMC. During this study 20 pregnant women suffering from constipation as defined by the Rome III criteria consumed 4 grams (1x109 CFU/gram) Ecologic® RELIEF daily. Participants recorded a.o. stool frequency and consistency, straining, sensation of incomplete defecation, abdominal pain and adverse events daily in a standardized bowel diary. Intake of Ecologic® RELIEF resulted in a significant increase in stool frequency; from 3.1 at baseline to 1 7 in week four (p < 0.01). In addition, compared to baseline, a significant decrease was found in straining (35%), sensation of incomplete evacuation (50%), sensation of anorectal obstruction (50%) and abdominal pain. No adverse effects were reported.7

Figure 3: Ecologic® RELIEF is able to significantly increase the bowel movements (A), decrease the faecal incontinence (B) and decrease abdominal pain (C).
Figure 3: Ecologic® RELIEF is able to significantly increase the bowel movements (A), decrease the faecal incontinence (B) and decrease abdominal pain (C). 

 

Ecologic® RELIEF publications

 

  • Bekkali N. et al. The role of a probiotics mixture in the treatment of childhood constipation: a pilot study. Nutr j 2007;6:17.
  • De Milliano I. et al. Is a multispecies probiotic mixture effective in constipation during pregnancy? A pilot study Nutr J 2012, 11:80.

Safety insurance

The use of oral probiotics has been well researched in many different (incl. vulnerable) patient populations, including infants, elderly people and immunocompromised patients. The general conclusion is that there are no safety risks for the studied bacterial strains in the dosages that were used in the studies. Caution is recommended in a number of highly vulnerable patient populations, such as oncology patients with severe leukopenia or mucositis. Probiotics use in acute pancreatitis is contraindicated. Read More about Safety…
 

World Wide availability

The research formulations of Ecologic® are not sold as consumer products. However our worldwide business partners offer a selection of the formulations their own branded product(s). Thus the specific bacterial compositions can be found in different products around the world.

References

  • 1. a. b. Bekkali N. et al. The role of a probiotics mixture in the treatment of childhood constipation: a pilot study. Nutr j 2007;6:17.
  • 2. Higgins P.D. et al. Epidemiology of constipation in North-America: a systematic review. Am J gastroenterol. 2004;99:750-759.
  • 3. a. b. Picard et al. Review article: Bifidobacteria as probiotic agent-physiological effects and clinical benefits. Aliment Pharmacol Ther. 2005;22:495-512.
  • 4. Zoppi et al. the intestinal ecosystem in chronic functional constipation. Acta Paediatr. 1998;87(8):836-841.
  • 5. Voskuijl W. et al. PEG 3350 (transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomized, controlled, multicenter trial. Gut. 2004;53:1590-1594.
  • 6. Dimidi E. et al. The effect of probiotics on functional constipation in adults: a systematic review and metaanalysis of randomized controlled trials. Am J Clin Nutr 2014;100:1075–84
  • 7. a. b. De Milliano I. et al. Is a multispecies probiotic mixture effective in constipation during pregnancy? A pilot study Nutr J 2012, 11:80.

Formulation ingredients

Bacterial strains

  • Bifidobacterium bifidum W23
  • Bifidobacterium lactis W52
  • Bifidobacterium longum W108
  • Lactobacillus casei W79
  • Lactobacillus plantarum W62
  • Lactobacillus rhamnous W71

Ingredients

  • Rice starch
  • Maltodextrin
  • Inulin
  • Fructo-oligosaccharides (FOS)
  • Mineral mix

Usage

Dosage dosage used in studies: 4 grams, 1 sachet
Daily CFU
Dissolve in luke water or dairy