Ecologic® BARRIER formulation inside

Ecologic Barrier figure 1
Figure 1: Ecologic® BARRIER is a multispecies probiotic developed to strengthen the intestinal barrier function and decrease inflammation.

Ecologic® BARRIER is a multispecies probiotic formulation. The bacterial strains have been selected for their capacity to strengthen the intestinal barrier and reduce low grade inflammation1 (figure 1).

For this, the strains were screened on their capacity to:

  • improve barrier function in vitro
  • inhibit mast cell activation
  • stimulate IL-10 production
  • break down LPS.

The selected strain combination from the Ecologic® Barrier formulation:

  • Bifidobacterium bifidum W23
  • Bifidobacterium lactis W52
  • Lactobacillus acidophilus W37
  • Lactobacillus brevis W63
  • Lactobacillus casei W56
  • Lactobacillus salivarius W24
  • Lactococcus lactis W19
  • Lactococcus lactis W58

Probiotic formulation for reduction of depressive sensitivity

Mental disorders, depression in particular, are becoming a global epidemic. Worldwide, more than 350 million people of all ages suffer from depression.2 A variety of lifestyle and environmental changes may be responsible for the increased prevalence of mental disorders. One specific area of interest is the relationship between the intestinal microbiota and mental health (figure 1).

Figure 2: The microbiota-gut-brain axis

The gut microbiota is essential for human health by protecting against pathogens and digesting food.3 However, the influence of the microbiota extends beyond the gastro- intestinal (GI) tract, playing an important role in the bidirectional communication between the GI tract and the central nervous system (CNS). This connection is also called the gut-brain axis.4 The high co-morbidity between psychiatric disorders with GI conditions such as irritable bowel syndrome and inflammatory bowel disease supports the evidence of the existence of this axis.5 6 7

The intestinal barrier appears to play an important role in the communication between the gut and the brain. Impaired barrier function negatively influences hormones, immune cells and bacterial metabolites that affect the gut-brain axis.

Research has shown that probiotics can positively influence the gut microbiota and intestinal barrier function. This raises the question whether probiotics can influence brain functioning as well. Recent studies have demonstrated the ability of probiotics to influence the gut-brain axis and by this brain functioning.8

Clinical support

Two studies with Ecologic® BARRIER have been performed related to depression both indicating a positive effect. In the first study, performed at Aarhus University, Denmark, healthy rats were given Ecologic® BARRIER or placebo for 8 weeks. After this period the animals performed a forced swim test, a typical screening for depressive-like behavior in rodents. The more depressed rats are, the less they move.

Ecologic Barrier figure 3
Figure 3: Seconds of immobility during the Forced Swim Test. The more depressed rats are, the less they move. *Significant decrease.

The group of animals that consumed Ecologic® Barrier moved significantly more compared to the placebo group9 (figure 3).

In the second study, a randomized, placebo- controlled human trial performed at Leiden University, the Netherlands, 40 students were given Ecologic® Barrier or placebo for 4 weeks. Before and after the intervention a validated questionnaire, the Leiden Index of Depression Sensitivity that measures cognitive reactivity in response to sad mood, was filled out. At baseline there were no differences between the two groups, but after 4 weeks the sensitivity to depression score was significantly decreased in the Ecologic® Barrier group compared to the placebo group (figure 4). The most pronounced decreases were found in the categories aggression and rumination.11 These positive results have led to a follow-up study in an elderly population. Multiple studies are currently planned or ongoing that further investigate the effect of Ecologic® BARRIER on a variety of mental disorders in diverse populations. The results indicate that supplementation with Ecologic® Barrier can influence the gut-brain axis and contribute to alleviating mental distress.

Ecologic Barrier figure 4
Figure 4: Scores on the Leiden Index of Depression Sensitivity (LEIDS-r) before and after 4 weeks use of Ecologic® BARRIER. *Significant decrease, P<0,001.

 

Publications on Ecologic® Barrier

 

  • van Hemert et al. Influence of the multispecies Probiotic Ecologic ® BARRIER on parameters of intestinal barrier function. Food and Nutrition Sciences 2014.
  • Abildgaard et al. Probiotic treatment alters behavior in rats on standard and high fat diet. Acta Neuropsychiatrica 2014;26:1 (abstract).
  • Steenbergen et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 2015;48:258-64.

Safety insurance

The use of oral probiotics has been well researched in many different (incl. vulnerable) patient populations, including infants, elderly people and immunocompromised patients. The general conclusion is that there are no safety risks for the studied bacterial strains in the dosages that were used in the studies. Caution is recommended in a number of highly vulnerable patient populations, such as oncology patients with severe leukopenia or mucositis. Probiotics use in acute pancreatitis is contraindicated. Read More about Safety…
 

World Wide availability

The research formulations of Ecologic® are not sold as consumer products. However our worldwide business partners offer a selection of the formulations their own branded product(s). Thus the specific bacterial compositions can be found in different products around the world.

References

  • 1. van Hemert et al. Influence of the multispecies Probiotic Ecologic® BARRIER on parameters of intestinal barrier function. Food and Nutrition Sciences 2014.
  • 2. WHO, factsheet N369, October 2012.
  • 3. Cho et al. The human microbe: at the interface of health and disease. Nat Rev Genet 2012;13:260-270.
  • 4. Cryan et al. Mind-altering micro organisms: the impact of the gut microbiota on brain and behavior. Nat Rev Neurosci 2012;13:701-712.
  • 5. Chen et al. The role of gut microbiota in the gut-brain axis: current challenges and perspectives. Protein Cell 2013;4(6):403-14.
  • 6. Dinan et al. Melancholic microbes; a link between gut microbiota and depression? Neuro gastro enterol Motil 2013; 25: 713-719.
  • 7. Borre et al. Microbiota and neuro developmental windows: implications for brain disorders. Tr in mol med 2014;20(9):509-18.
  • 8. Collins et al. The interplay between the intestinal microbiota and the brain. Nature Reviews Microbiolog 2012; 10: 735-742.
  • 9. Abildgaard et al. Probiotic treatment alters behavior in rats on standard and high fat diet. Acta Neuropsychiatrica 2014;26:1 (abstract).
  • 11. Steenbergen et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 2015;48:258-64.

Formulation ingredients

Bacterial strains

  • Bifidobacterium bifidum W23
  • Bifidobacterium lactis W52
  • Lactobacillus acidophilus W37
  • Lactobacillus brevis W63
  • Lactobacillus casei W56
  • Lactobacillus salivarius W24
  • Lactococcus lactis W19
  • Lactococcus lactis W58

Usage

Dosage Dosage used in studies: 2 grams per day
Daily CFU
Dissolve in luke water or dairy